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超声刺激的BMSCs通过近效应促进耐火足的再生愈合

Yilin Tang¹, Haopeng Xu¹, Sicheng He¹

¹State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, China.

Ultrasound in medicine & biology

|September 10, 2025

概括

低强度脉冲超声波 (LIUS) 预治疗增强了骨髓介质干细胞 (BMSCs) 对于糖尿病足 (DFU) 愈合. 这种组合疗法通过免疫调节和增强再生促进伤口修复.

科学领域:

再生医学是一种再生医学.
生物材料科学生物材料科学
伤口治愈研究研究伤口治愈研究

背景情况:

糖尿病足 (DFU) 是严重的糖尿病并发症,导致截肢和降低生活质量.
骨髓介质干细胞 (BMSCs) 对慢性伤口具有治疗潜力,但在生存和疗效方面存在局限性.
低强度脉冲超声波 (LIUS) 可以增强BMSC的生物行为,这表明一种协同治疗方法.

研究的目的:

为糖尿病足 (DFU) 建立一个强大的老鼠模型,模仿临床病理学.
评估低强度脉冲超声波 (LIUS) 预处理的骨髓介质干细胞 (BMSCs) 在促进DFU愈合方面的有效性.
在DFU治疗中研究LIUS增强BMSC治疗的潜在机制.

主要方法:

建立了一个DFU大鼠模型,使用股骨神经切割,股骨动脉绑定和全厚皮肤去除.
该DFU模型用LIUS预处理的BMSCs进行了治疗,并评估了伤口愈合.
分析了组织病理学变化,原纤维的形成,血管新生以及炎症和愈合相关因素的表达.

主要成果:

已建立的DFU大鼠模型有效地模拟了临床缺血和神经病症状况,显示伤口愈合延迟和原沉积受损.
LIUS预先治疗的BMSC通过促进M2巨细胞极化和调节炎症反应,显著增强了伤口修复.
治疗上调了诸如VEGF-A,SDF-1,CXCR4和NGF等关键因素,刺激了血管生成和神经再生,从而改善了再上皮化和原形成.

结论:

成功开发了一种可靠的DFU大鼠模型,准确地反映了临床疾病状态.
LIUS预治疗显著提高了BMSCs在DFU治愈中的治疗效果.
这种综合疗法为在糖尿病伤口管理中推进基于干细胞的治疗提供了一个有希望的策略.

关键词:

骨髓中介细胞干细胞是骨髓中介细胞的干细胞.低强度超声波低强度的超声波.帕拉克林效应的作用耐火性足部的治疗方法

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