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Updated: Jan 18, 2026

Author Spotlight: Understanding DNA Damage Response in Mammalian Oocytes and Preimplantation Embryos
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不足的端粒DNA损伤反应促进了老化卵细胞中的染色体不稳定性

Tianqi Cao1, Simiao Liu1, Fang Wang2

  • 1MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, China.

Science bulletin
|September 10, 2025
PubMed
概括

老化的卵细胞积累了端粒DNA损伤,导致染色体不稳定. 这项研究表明,端粒DNA损伤反应 (DDR) 激活了断裂诱导的端粒合成 (BITS),但这种过程在老化卵细胞中不足.

关键词:
衰老的衰老 衰老的衰老造成的DNA损伤是DNA损伤.对DNA损伤的反应反应卵子细胞是卵子细胞.泰洛米尔 (Telomere) 是一种电离体.

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