纳米纤维超分子水凝用于控制释放小分子药物和生物制剂
Brett H Pogostin1, Samuel X Wu1, Michael J Swierczynski2
1Department of Bioengineering, Rice University, Houston, TX, USA.
Nature nanotechnology
|September 10, 2025
概括
新的自组装酸盐释放 (SABER) 多域形成水凝,延长药物释放. 这种药物输送创新延长了小分子和生物制剂的治疗效果,显示出临床应用的前景.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 维持体内安全有效的药物度是很困难的.
- 来自多域的超分子水凝由于它们的多孔纳米结构,为药物输送提供了潜在的可能性.
- 药物释放时间有限是当前水凝系统面临的关键挑战.
研究的目的:
- 开发用于延长药物释放的新型多域.
- 为了创建自组装的酸盐释放 (SABER) ,利用动态共价键.
- 为了证明SABER水凝在传递各种治疗有效载荷方面的有效性.
主要方法:
- 自组装酸释放 (SABER) 多域的设计和合成.
- 形成能够与含酸的有效载荷进行动态共价键的超分子凝.
- 在感染和糖尿病模型中使用小分子药物 (ganfeborole) 和生物制剂 (胰岛素,抗体) 的体内药理学研究.
主要成果:
- SABER水凝成功地延长了含酸的药物和生物制剂的释放时间.
- 药理动力学研究表明,甘菲博洛的治疗效果从几天延长到几周,抑制了Mycobacterium tuberculosis的生长.
- 通过延长胰岛素活性,SABER水凝的单次注射在糖尿病小鼠中维持了6天的血糖正常.
结论:
- SABER多域形成水凝,有效地克服了快速药物扩散的限制.
- 动态共价键策略使各种治疗剂的持续释放成为可能.
- 在药物输送中,SABER 水凝具有广泛的临床转化潜力.
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