哈拉索尔戈迪默A-E,来自海洋衍生Chaetomium sp.的多重聚合模式的异构体. 的真菌是一种真菌
Ze-Hong Lin1, Han-Wen Shan1,2, Li-Kun Yang3
1College of Pharmaceutical Sciences, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Hebei University, Baoding, 071002, People's Republic of China.
Natural products and bioprospecting
|September 10, 2025
概括
海洋真菌产生了新的异构体和单构体. 一些化合物,如沙拉索尔戈迪默,对肺癌细胞表现出显著的细胞毒性活性,其中化合物12特别有效.
科学领域:
- 自然产品化学 自然产品化学
- 海洋微生物学 海洋微生物学
- 药用化学 医学化学
背景情况:
- 海洋衍生真菌是结构多样化的二次代谢物的丰富来源.
- 众所周知,chaetomium物种产生生物活性化合物,包括chaetoglobosins.
研究的目的:
- 从一种海洋衍生物Chaetomium sp.中分离和描述新的异构体化合物. 这是一种真菌.真菌.
- 针对人类非小细胞肺癌细胞的分离化合物的细胞毒性活性进行研究.
主要方法:
- 使用色谱技术分离和净化化合物.
- 使用高分辨率电子喷雾电离质谱 (HRESIMS),核磁共振 (NMR) 谱学 (包括13C NMR) 和电子循环二元化 (ECD) 方法阐明结构.
- 使用A549细胞系进行细胞毒性测定.
主要成果:
- 他们分离了五种新的异构体 (chalasoergodimers A-E,1-5),三种已知的异构体 (6-8),以及四种甲蛋白素单体 (9-12).
- 化合物1代表了一种新的二元化模式,介于一个chaetoglobosin和一个ergosterol衍生物之间.
- 化合物3-5是通过Diels-Alder循环加法形成的.
- 化合物9-12对A549细胞表现出显著的细胞毒性活性,其中化合物12显示出最强效 (IC50 = 5.14μM).
结论:
- 该研究确定了来自海洋真菌的独特结构特征的新型异构体化合物.
- 已分离的甲基球蛋白单体显示出作为抗癌剂的潜力,特别是对抗非小细胞肺癌.
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