在癌症和免疫微环境中的TCA循环衍生性甲基化合物
Shukla Sarkar1, Chien-I Chang1, Jussekia Jean1
1Division of Gastroenterology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Journal of biomedical science
|September 10, 2025
概括
代谢代谢产物,如2-基质酸盐 (2-HG),糖酸盐和烟酸盐,是推动瘤进展和免疫逃避的代谢副产品. 针对这些代谢物提供了新的癌症治疗策略.
科学领域:
- 生物化学 生物化学
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 代谢代谢物是突变的三碳酸 (TCA) 循环酶的代谢副产品.
- 关键的代谢物 (2-HG,酸盐,酸盐) 抑制了二氧化原酶,影响了表观遗传学,分化和缺氧.
- 伊塔科纳酸是一种免疫代谢物,可调节炎症和瘤免疫力.
研究的目的:
- 审查TCA循环关联的代谢物在癌症生物学和免疫调节中的作用.
- 讨论这些代谢物如何影响瘤内在过程和瘤微环境.
- 检查针对对cometabolite通路的治疗策略,以改善癌症治疗.
主要方法:
- 在癌症中对代谢功能的文献综述.
- 分析机制,包括表观遗传重编程,氧化还原平衡和蛋白质修饰.
- 检查针对可可代谢途径的治疗干预措施.
主要成果:
- 代谢物影响瘤进展和免疫逃避.
- 这些代谢物影响癌细胞和瘤微环境 (T细胞,巨细胞等). ) 的情况.
- 代谢物重编程免疫反应,导致免疫抑制.
结论:
- 与TCA循环相关的代谢物是癌症发展和免疫力的关键调节剂.
- 准甲基代谢物可以恢复免疫监测并增强癌症治疗.
- 对免疫代谢干预的进一步研究对癌症治疗有希望.
相关概念视频
02:17The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
01:27Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
02:18Cancer
53.5K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.5K
01:33Cancer-Critical Genes I: Proto-oncogenes
11.2K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.2K
02:30Metastasis
6.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.4K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
9.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.4K