相关实验视频

Updated: Jan 18, 2026

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness

Published on: March 14, 2025

交替磁场可以去除生物膜,但在植入物模型上也会损害细胞,并且可以忽略大量加热

Konstantin Nikolaus Beitl¹, Sandra Pérez-Jiménez¹, Guruprakash Subbiahdoss¹

¹Institute of Colloid and Biointerface Science, Institute of Colloid and Biointerface Science, BOKU University, 1190 Vienna, Austria.

ACS applied materials & interfaces

|September 11, 2025

概括

交替磁场 (AMF) 可以在植入物上根除金黄色葡萄球菌生物膜. 然而,该机制涉及机械干扰,而不仅仅是加热,并造成周围细胞的附带损伤,需要进一步研究以确保安全的临床使用.

科学领域:

生物材料科学生物材料科学
传染性疾病传染性疾病
医学物理医学物理

背景情况:

由细菌生物膜引起的植入物相关感染是一个重大的临床挑战.
目前的治疗方法通常涉及长时间的抗生素治疗或植入物修复手术.
需要一些非侵入性的替代方法来管理这些感染.

研究的目的:

调查交替磁场 (AMF) 在植入物表面上根除金黄色葡萄球菌生物膜的有效性.
为了阐明AMF抗菌作用背后的机制.
评估AMF治疗哺乳动物细胞的安全性和潜在细胞毒性.

主要方法:

植入物模型表面被注射金黄色葡萄球菌以形成生物膜.
对生物膜覆盖的表面施加了AMF暴露.
评估了细菌的活力和生物膜的去除.
对热效应进行了监测,并与非热机制进行了比较.
细胞毒性在SaOS-2骨质母细胞样细胞上进行了评估.

主要成果:

暴露于AMF有效地去除了金黄色葡萄球菌生物膜,并降低了细菌的活力.
抗微生物药物的有效性主要归因于机械干扰,可能是通过化,而不是仅仅是热效应.
治疗AMF对邻近的哺乳动物细胞造成了显著的损伤,包括细胞骨分解和膜穿孔.
即使在短时间暴露于AMF后,也观察到附带细胞毒性.

结论:

治疗AMF显示出消除植入物上的细菌生物膜的潜力.
主要机制似乎是机械破坏,而不是热效应.
对哺乳动物细胞显著的细胞毒性需要进一步的研究,以确保安全的临床应用.
开发基于AMF的临床安全和有效的感染管理策略需要解决观察到的附带损害.

关键词:

黄金葡萄球菌黄金葡萄球菌交替磁场的交替磁场是什么生物膜是一种生物膜.洞化洞化洞化磁力加热磁力加热金属植入物是金属植入物.骨质母细胞 (osteoblasts) 是一个骨质细胞.的是什么的是什么

更多相关视频

Oral Biofilm Formation on Different Materials for Dental Implants

Oral Biofilm Formation on Different Materials for Dental Implants

Published on: June 24, 2018

Pilot In Vitro Study to Assess Cleaning Ability and Effects of Different Decontamination Methods on Implant Surfaces

Pilot In Vitro Study to Assess Cleaning Ability and Effects of Different Decontamination Methods on Implant Surfaces

Published on: November 21, 2025

相关概念视频

Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

Physical Methods for Controlling Microbial Growth: Radiation and Filtration

Physical Methods for Controlling Microbial Growth: Radiation and Filtration

Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.

Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...