在心电图上通过恒温失调评估的,预测骨折和死亡率
Namki Hong1,2,3, Sang Wouk Cho4,5, Jungheui Kim4,5
1Division of Endocrinology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
增加心律障碍 (ECG-HD) 与成人骨折风险和死亡率较高有关. 这种心脏的测量预测骨健康和整体存活率,独立于年龄和骨密度.
科学领域:
- 生物医学工程 生物医学工程
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 生物系统呈现出越来越多的混乱,或,可量化为恒温失调 (HD).
- 马哈拉诺比斯距离 (DM) 接近个体水平的HD,在心电图 (ECG) 分析中具有潜在的应用.
- 肌肉骨健康和心脏功能是相互关联的,与年龄相关的变化影响两者.
研究的目的:
- 调查是否更大的ECG衍生的HD与肌肉骨系统的HD相关.
- 为了确定ECG-HD是否可以预测骨折风险,而不考虑年龄,骨矿物质密度 (BMD) 和先前的骨折史.
- 评估ECG-HD与全因死亡风险之间的关联.
主要方法:
- 对7738名成年人 (≥40岁) 队列的分析,使用查12心电图数据.
- 计算ECG-HD使用Mahalanobis距离 (DM) 的五个ECG参数 (心室速率,QRS持续时间,纠正的QT间隔,R轴,T轴) 相对于年轻成年人.
- 骨折事件和死亡率的纵向随访.
主要成果:
- 电脑心电图-高频率显示出与年龄的正相关性 (r=0.28).
- 每次ECG-HD标准偏差增加都与48%更高的未调整骨折风险有关,在调整后仍然显著 (aHR 1.28).
- 电脑心电图-HD显著与脊椎,非脊椎,关节骨折和全因死亡率相关 (aHR 1.44).
结论:
- 电脑心电图 (ECG-HD) 作为心脏和平稳性失调的可量化的衡量标准.
- 升高的ECG-HD是成年人骨折风险的独立预测因子.
- 增加的ECG-HD与更高的全因死亡风险有关,突出了其超出心脏诊断的预后价值.
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