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自然启发的IL-1向疗法用于治疗慢性炎症疾病

Yeon-Suk Yang1, Mi-Jeong Kim1, Sachin Chaugule1

  • 1Department of Medicine, UMass Chan Medical School, Worcester, MA, USA; Department of Genetic and Cellular Medicine, UMass Chan Medical School, Worcester, MA, USA; Horae Gene Therapy Center, Worcester, MA, USA.

Molecular therapy : the journal of the American Society of Gene Therapy
|September 11, 2025
PubMed
概括

使用复合腺相关病毒 (rAAV) 的新型基因疗法产生可诱导炎症的互白素-1受体对抗剂 (sIL-1Ra). 这种方法通过向IL-1通路,有效治疗小鼠的炎症性关节炎.

关键词:
在 AAV AAV AAV 中.迪拉 (Diara) 是一个日期.关节性骨质侵蚀 关节性骨质侵蚀自发炎性疾病是自发炎性疾病.骨质损失导致骨质损失.类风湿性关节炎 类风湿性关节炎sIL-1Ra 是一个

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