大脑的微观结构变化及其对老年外科手术患者手术后痴呆症的影响:叙述性综述
Yali Chen1, Huanyu Luo1, Jing Dong1
1Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Brain and behavior
|September 11, 2025
概括
预先存在的大脑微观结构变化可能会增加老年患者手术后妄 (POD) 的风险. 针对大脑微观结构的干预可以帮助减少POD发生率.
科学领域:
- 神经科学是一个神经科学.
- 老年医学 老年医学
- 放射学 放射学是一门学科.
背景情况:
- 手术后妄 (POD) 是老年患者常见的并发症,其预测因子和机制尚不清楚.
- 大脑微观结构的改变越来越多地被认为是导致认知衰退和神经疾病的潜在贡献者.
研究的目的:
- 审查关于大脑微观结构变化和POD之间的关联的新兴证据.
- 探索认知储备的作用和针对大脑微观结构的潜在干预措施.
主要方法:
- 现有文献的叙述性审查.
- 分析老化大脑中的微观结构变化.
- 检查微结构性MRI发现及其与POD的关系.
主要成果:
- 预先存在的大脑微观结构变化可能会使老年人易患POD.
- 灰色/白质组织的变化影响大脑衰老和认知储备.
- 先进的神经成像对于理解POD病原和预测至关重要.
结论:
- 大脑的微观结构完整性与POD风险有关.
- 旨在增强大脑微观结构的干预措施可能会减轻POD的发展.
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