认知补偿依赖于前端对称网络结构-功能合在患有白质超强度的患者中
Xiao Zhu1, Yifei Li1, Ying Zhou1
1Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Brain and behavior
|September 11, 2025
概括
在前端对称网络中,网络结构-功能合 (SC-FC合) 可能有助于在早期白质超强度 (WMH) 阶段保持认知. 这一发现表明SC-FC合可能是维护WMH患者认知功能的干预措施的目标.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 脑血管疾病研究研究
背景情况:
- 白质过强度 (WMH) 与认知能力下降有关,但早期机制尚不清楚.
- 研究网络结构-功能合 (SC-FC合) 对于了解早期WMH对认知的影响至关重要.
研究的目的:
- 探索网络SC-FC合在WMH患者认知表现中的作用.
- 为了确定SC-FC合模式在轻度和重度WMH阶段之间是否有差异,并与认知功能相关.
主要方法:
- 从CIRCLE研究中对617名WMH患者的回顾性分析,使用多模式MRI和认知评估.
- 从扩散张力成像和功能性MRI数据计算网络SC-FC合.
- 基于Fazekas评分对周周结节和深层WMH的WMH严重程度的分类.
主要成果:
- 面对对面的网络显示出最低的SC-FC合,而体机运动网络在所有参与者中显示出最高的水平.
- 在轻度的WMH中,前端双SC-FC合与WMH体积和数字跨度前进任务上的认知表现正相关.
- 在整个队列或严重WMH亚组中没有观察到这些相关性.
结论:
- 前端对联网络SC-FC合可能会促进WMH早期的认知补偿.
- SC-FC合代表了旨在维护WMH患者认知功能的干预措施的潜在治疗目标.
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