脂瘤瘤中的Palbociclib:来自土耳其瘤学集团 (TOG) 的现实世界多中心数据
Fatih Kus1, Hasan Cagri Yildirim2, Dogan Bayram3
1Department of Medical Oncology, Hacettepe University, Ankara, Turkey.
Journal of chemotherapy (Florence, Italy)
|September 11, 2025
概括
在超过一半的晚期脂肪瘤患者中,Palbociclib单一治疗显示出疾病控制,但显示出适度的活性. 对生物标志物驱动和组合疗法的进一步研究是有必要的,以改善区分良好 (WDLPS) 和非区分性脂肪肉瘤 (DDLPS) 的结果.
科学领域:
- 在瘤学瘤学.
- 医学科学 医学科学 医学科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 区分良好的脂肉瘤 (WDLPS) 和不区分的脂肉瘤 (DDLPS) 是不同的亚型,通常是由CDK4放大驱动的.
- 像palbociclib这样的CDK4/6抑制剂显示出治疗前景,但对脂质肉瘤治疗的现实世界数据有限.
研究的目的:
- 评估palbociclib单一治疗在晚期WDLPS或DDLPS患者中的实际有效性和安全性.
- 评估无进展生存期 (PFS),总生存期 (OS),反应率和与palbociclib治疗相关的不良事件.
主要方法:
- 对21名晚期WDLPS或DDLPS患者的回顾性分析,这些患者接受了palbociclib单一治疗.
- 2019年至2022年间,从16个土耳其瘤集团中心收集的数据.
- 评估的结果包括PFS,OS,客观反应率 (ORR),疾病控制率 (DCR) 和安全概况.
主要成果:
- 中位数PFS为5.3个月,中位数OS为9.1个月.
- 没有观察到客观反应 (ORR为0%),但在57.1%的患者中实现了疾病控制.
- 常见的不良事件包括贫血 (52.4%) 和中性质减退 (33.3%); 71.4%的人经历了一些不良事件.
结论:
- 帕尔博西克利布单一疗法表现出适度的活性,在一小部分晚期脂瘤瘤患者中观察到疾病稳定.
- 这些发现强调了需要基于生物标志物的方法和组合策略来提高WDLPS和DDLPS的治疗疗效.
相关概念视频
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There are several types of targeted therapies against specific...
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Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

