在患有癌症的儿童中使用抗菌剂耐受性黄金葡萄球菌的殖民:一项纵向研究
J Chase McNeil1,2, Lauren M Sommer1,2, Marritta Joseph1,2
1Baylor College of Medicine, Department of Pediatrics and Texas Children's Hospital, Houston, TX, USA.
Infection control and hospital epidemiology
|September 11, 2025
概括
抗菌剂耐受性金黄色葡萄球菌 (ATSA) 殖民是短暂的,在儿科瘤患者中并不比健康儿童更常见. 重复使用消毒剂似乎不会增加门诊机构的ATSA殖民率.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 临床研究 临床研究
背景情况:
- 黄金葡萄球菌的抗菌耐受性与qacA/B和smr基因有关,从而产生抗菌耐受性黄金葡萄球菌 (ATSA).
- 经常接触消毒剂对ATSA殖民性的影响,特别是在医疗保健环境中,仍然不清楚.
- 了解ATSA殖民动态对于预防感染策略至关重要.
研究的目的:
- 调查与健康儿童相比,儿科瘤患者中ATSA殖民的患病率和持续时间.
- 为了确定反复暴露于杀菌剂,如氧氨酸葡萄酸盐 (CHG),是否会影响ATSA殖民.
- 评估医疗保健暴露对ATSA殖民率的影响.
主要方法:
- 一项前性纵向队列研究,涉及患有恶性瘤 (高风险) 和健康儿童 (低风险) 的儿童.
- 鼻腔和下腔培养在一年内每季度收集.
- 用PCR检测S. aureus分离体中的qacA/B和smr基因;逻辑回归调整以考虑混因素.
主要成果:
- 在15.5%的受试者中检测到ATSA殖民.
- 最初,低风险队列显示出更高的ATSA殖民,但调整后的分析显示,高风险和低风险组之间的比例相似.
- 与ATSA的殖民是短暂的,只有两名受试者在多个时间点经历了它.
结论:
- 儿科瘤患者的ATSA殖民率并不比健康儿童高.
- ATSA殖民是短暂的,这表明经常使用消毒剂,包括CHG,不会导致在门诊环境中持续的殖民.
- 目前的感染预防实践在ATSA殖民方面似乎是安全的.
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