在化品中使用的可能的内分泌干扰化学品的库存
Manon C Bouwmeester1, Gaby A M Eliesen2, Jeroen L A Pennings1
1Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Critical reviews in toxicology
|September 11, 2025
概括
由于内分泌干扰化学物质 (EDCs),化品成分的安全性是一个问题. 一个新的工作流确定了化品中27种潜在的EDC,其中基拉尼被认为是安全的,并优先考虑其他用于进一步审查.
科学领域:
- 化品科学 化品科学
- 毒理学 毒理学 毒理学
- 环境健康 环境健康
背景情况:
- 化品成分引发了对内分泌干扰 (ED) 潜力的安全担忧.
- 化品中对内分泌干扰化学物质 (EDC) 的总体暴露可能会造成健康风险.
研究的目的:
- 开发和应用工作流程来选化品成分的潜在EDC.
- 评估特定化学品的安全性,比如化品中使用的格拉尼奥尔.
- 优先考虑化品成分,以进一步评估其ED特性.
主要方法:
- 从Mintel数据库中获取荷兰市场的化品成分数据.
- 与开源EDC数据库 (ECHA,国家当局,非政府组织) 进行交叉引用的成分列表.
- 开发了一种工作流程,以识别和分类潜在的EDC并评估总体暴露风险.
主要成果:
- 选了890种化品成分,确定了27种"对ED特性有迹象"和1种"对ED特性没有关注".
- 预先的安全评估表明,关于内分泌风险的美容用品,格拉尼奥尔是安全的.
- 优先考虑58种成分进行进一步查,其中8种显示"ED特性有限的迹象".
结论:
- 开发的工作流程有效地选化品的潜在EDC,并优先考虑化学品的安全评估.
- 根据目前的数据,基拉尼奥尔在化品中的安全使用表明了与内分泌相关的健康风险.
- 工作流程有助于评估化品成分的安全使用,并识别潜在的EDC.
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