相关实验视频
Updated: Jan 18, 2026

12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
19.3K
开源自动化胰岛素输送 (AID) 系统-AndroidAPS的切换到商用AID系统在1型糖尿病:扩展CODIAC研究的扩展
Quoc Dat Do1,2, Lucie Radovnická2,3, Aneta Hásková1,2
13rd Department of Internal Medicine, General University Hospital, Prague, Czech Republic.
Diabetes technology & therapeutics
|September 11, 2025
概括
在像AndroidAPS这样的开源自动化胰岛素输送 (OS-AID) 和商业系统 (Control-IQ,MiniMed 780G) 之间的切换显示了类似的时间范围. AndroidAPS在窄距离中提供了更长的时间,但增加了低血糖的风险.
科学领域:
- 内分泌学和新陈代谢学
- 生物医学工程 生物医学工程
- 临床糖尿病研究临床糖尿病研究
背景情况:
- 自动注射胰岛素 (AID) 系统为1型糖尿病 (T1D) 提供先进的血糖控制.
- 像AndroidAPS (AAPS) 这样的开源AID (OS-AID) 系统提供了可定制的选项.
- 商业AID系统,包括Control-IQ (CIQ) 和MiniMed 780G (780G),代表了广泛采用的技术.
研究的目的:
- 调查在OS-AID系统AAPS和商业AID系统CIQ和780G之间切换的临床结果.
- 为了比较血糖控制指标,包括时间在范围 (TIR),时间在狭窄范围 (TITR) 和低血糖,在不同的AID系统使用阶段.
- 评估AID系统切换对T1D成年人血糖控制的影响.
主要方法:
- 一个前性的,开放的,单臂临床试验,涉及41名T1D成年人.
- 参与者使用AAPS3个月,然后切换到CIQ (n=25) 或780G (n=16) 3个月,然后返回AAPS3个月.
- 通过测量HbA1c,TIR,TITR和低血糖 (<70 mg/dL) 的时间来评估血糖控制.
主要成果:
- 商业的AID系统显示,与AAPS (84.2%与85%) 相比,其射程时间 (TIR) 是可比的.
- 时间在紧密范围 (TITR) 显著高于AAPS (66.4%对63.4%,P=0.035).
- 低血糖的时间 (<3.9 mmol/L) 在商业系统 (2.2%对3.8%,P<0.001) 显著降低.
结论:
- 从AAPS切换到商业AID系统并没有显著改变TIR在T1D的成年人.
- 与商业系统相比,AAPS使用与更高的TITR相关,但也增加了低血糖的风险.
- 这项研究提供了关于在OS-AID和商业AID系统之间切换的独特前性数据.
相关概念视频
Insulin Formulations: Types and Delivery
663
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
Short-acting insulins are divided into...
663
Insulin: Dosing Regimen and Adverse Effects
695
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
695
Diabetes Mellitus: Overview and Type I Subtype
4.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.9K
Diabetes: Management and Pharmacotherapy
870
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
870
Insulin: Biosynthesis, Chemistry, and Preparation
1.2K
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
1.2K
Diabetes Mellitus: Type 2 and Gestational
4.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.4K

