Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.4K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Beyond AI-Driven Curve Fitting: Mechanistic Insight as the Cornerstone of Reliable Sensing and Accurate Fitting.

Small methods·2026
Same author

Vorinostat Rescues Cognitive Deficits in a Neuroinflammatory Mouse Model: A Study of Sex Differences and the Underlying TLR4/NF-κB Mechanism.

Neurochemical research·2026
Same author

From polyamine metabolism genes to immunoproteasome subunits: a transcriptome-based screening of candidate biomarkers in Crohn's disease.

Scientific reports·2026
Same author

Stimuli-responsive nanocarriers for precision targeted and controlled antimicrobial drug delivery in drug-resistant infections.

Frontiers in microbiology·2026
Same author

Hydration Performance Enhancement Mechanism of Steel Slag-Based Cementitious Materials: Synergistic Regulation of Sodium Silicate and Triethanolamine Complexation.

Materials (Basel, Switzerland)·2026
Same author

Catalogue of type specimens of <i>Sarcophaga</i> Meigen deposited in Shanghai Entomological Museum (Diptera, Sarcophagidae).

ZooKeys·2026

相关实验视频

Updated: Jan 18, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

10.1K

用siRNA纳米复合体调节产卵前的胎盘功能

Xue Peng1,2, Xi Tan1,2, Li Dai1,2

  • 1Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu (X.P., X.T., L.D., W.X.).

Hypertension (Dallas, Tex. : 1979)
|September 11, 2025
PubMed
概括

这项研究揭示了线粒体DNA拷贝数和子宫前之间的联系. 它还引入了通过DMD@DPF纳米颗粒传递的siRNA SENP3,作为早期发作的先兆子的潜在治疗方法.

关键词:
这些都是DNA,线粒体DNA.门德尔的随机化分析.胎盘 胎盘 胎盘 胎盘孕产妇产前炎症 (pre-eclampsia) 是一个严重的疾病.怀孕 怀孕 怀孕 怀孕 怀孕

更多相关视频

siRNA Transfection and EMSA Analyses on Freshly Isolated Human Villous Cytotrophoblasts
09:57

siRNA Transfection and EMSA Analyses on Freshly Isolated Human Villous Cytotrophoblasts

Published on: September 20, 2016

11.1K
Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

9.2K

相关实验视频

Last Updated: Jan 18, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

10.1K
siRNA Transfection and EMSA Analyses on Freshly Isolated Human Villous Cytotrophoblasts
09:57

siRNA Transfection and EMSA Analyses on Freshly Isolated Human Villous Cytotrophoblasts

Published on: September 20, 2016

11.1K
Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

9.2K

科学领域:

  • 遗传学 是一个遗传学.
  • 分子生物学分子生物学
  • 生殖医学 生殖医学

背景情况:

  • 早期发病的孕前对母亲和胎儿的健康构成严重风险.
  • 了解它的分子基础对于开发有效的治疗方法至关重要.

研究的目的:

  • 为了研究线粒体DNA拷贝数和孕前之间的关系.
  • 探索SENP3和SETD7在孕前病原发生中的作用.
  • 开发和评估一种新的治疗策略,用于产前.

主要方法:

  • 全基因组关联研究 (GWAS) 和门德尔的随机化分析.
  • 转录组测序,体外实验和动物模型.
  • 通过DMD@DPF纳米粒子传递的siRNA SENP3的开发和测试.

主要成果:

  • 在线粒体DNA拷贝数和孕前之间观察到负相关性.
  • SENP3和SETD7在产前的胎盘中显示出显著的差异性表达.
  • 通过DMD@DPF纳米颗粒传递的siRNA SENP3在生育前症小鼠模型中表现出治疗效果.

结论:

  • 在产前的病理生理学中,SENP3和SETD7起着至关重要的作用.
  • 通过DMD@DPF纳米颗粒传递的siRNA SENP3代表了孕前的有希望的治疗途径.