手术后的阿片类药物接收在口腔切除术后和与持续的阿片类药物使用障碍的关联
Asher C Park1, Milan P Fehrenbach2, Larry W Wang1
1Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
概括
切除术后的术后阿片类药物使用增加了持续阿片类药物使用障碍和更多的办公室访问的风险. 对阿片类药物缓解疼痛的进一步研究至关重要.
科学领域:
- 在瘤学瘤学.
- 疼痛管理 疼痛管理
- 外科手术 手术手术
背景情况:
- 腺切除术是腺瘤的手术,通常涉及术后疼痛管理.
- 片类止痛药通常被处方,这引发了人们对潜在的长期使用和依赖的担忧.
研究的目的:
- 为了调查接受膜切除术后的阿片类药物与发展持久性阿片类药物使用障碍之间的联系.
- 分析术后阿片类药物接收对医疗保健利用和阿片类药物依赖风险的影响.
主要方法:
- 使用TriNetX研究网络 (2010-2023) 进行的一项倾向匹配的回顾性队列研究.
- 分析了经过切除术的成年患者,但不包括以前滥用阿片类药物或最近麻醉的患者.
- 在阿片类药物和非阿片类药物队列中,根据人口统计,诊断和并发程序,倾向性匹配.
主要成果:
- 与非阿片类药物队列相比,阿片类队列 (n=3858) 显示了与非阿片类药物队列相比,新的持续阿片类药物使用风险显著增加 (RR=1.321,P<.001).
- 服用阿片类药物与术后1个月和3个月更多的办公室/门诊访问有关 (P<.001).
- 在急诊室访问或阿片类药物滥用/依赖的风险方面没有发现显著差异.
结论:
- 胸膜切除术后的阿片类药物处方与持久性阿片类药物使用障碍的更高风险有关.
- 术后办公室访问的增加也与最初的阿片类药物处方有关.
- 这些发现凸显了对膜切除术患者的阿片类药物节约性止痛方案的需要.
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