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对于YAP1依赖的恶性和再生性肝细胞到胆细胞重编程,需要SALL4

Minwook Kim1,2, Yoojeong Park1, Rachel Covitz1

  • 1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Cancer research communications
|September 11, 2025
PubMed
概括

裂纹样转录因子4 (SALL4) 调节肝细胞的可塑性,影响肝癌的发展和修复. 向YAP1-SALL4-BMI1通路为胆管癌提供了一个潜在的治疗策略.

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