基于酵母的Saccharomyces cerevisiae补充剂和母乳供应:一个随机的安慰剂控制试验
Lili Jia1, Louise Brough2, Janet L Weber2
1College of Sciences, Massey University, Palmerston North, New Zealand.
Maternal & child nutrition
|September 11, 2025
概括
基于Saccharomyces cerevisiae酵母的补充剂 (SCYS) 并没有改变母乳寡糖化物 (HMO) 的含量. 然而,SCYS改善了母亲对牛奶供应的看法,并减少了配方奶粉的使用,这表明对母乳养妇女有潜在的益处.
科学领域:
- 哺乳期和母乳养研究
- 营养科学 营养科学
- 人类牛奶的成分 人类牛奶的成分
背景情况:
- 以Saccharomyces cerevisiae酵母为基础的补充剂 (SCYS) 通常被用作增强牛奶产量的银河物质.
- 支持SCYS在改善牛奶供应和成分方面的有效性证据有限.
- 人类牛奶寡糖 (HMO) 对婴儿肠道健康和免疫发育至关重要.
研究的目的:
- 调查SCYS对母乳中的母乳寡糖化物 (HMO) 度的影响.
- 评估SCYS对感知牛奶供应和其他母亲和婴儿结果的影响.
- 为了评估SCYS作为银河战斗机的安全性和有效性.
主要方法:
- 一项随机对照试验,涉及68名母乳养妇女及其婴儿 (年龄为1-7个月).
- 参与者每天服用SCYS5g或安慰剂4周.
- 主要结果是HMO总度的变化;次要结果包括感知到的牛奶供应,婴儿养模式和不良影响.
主要成果:
- 补充SCYS并没有显著改变个人或总HMO度.
- 与安慰剂组相比,SCYS组的女性比例更高 (65%) 感觉到牛奶产量增加 (35%).
- 使用SCYS与改善母亲对牛奶数量和质量的感知以及在分娩后6个月显著降低配方奶粉的使用有关.
结论:
- SCYS似乎不会影响母乳中的HMO度.
- SCYS可能会积极影响母乳养母亲对母乳供应的看法.
- 需要进一步的随机对照试验来证实对实际牛奶产量和成分的影响.
相关概念视频
Yeast Signaling
17.2K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.2K
Bioavailability Study Design: Single Versus Multiple Dose Studies
217
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
217
Bioavailability Study Design: Healthy Subjects Versus Patients
144
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
144


