基于膀形态特征的完全端到端的自动膀细分和风险评估,用于预测上部泌尿道功能障碍
Zhonghan Zhou1,2,3,4, Hang Tianyang5, Juan Wu1,2,3,4
1School of Rehabilitation of Capital Medical University; Department of Urology, China Rehabilitation Research Center, Beijing, China.
International journal of surgery (London, England)
|September 11, 2025
概括
膀形态特征准确地预测上泌尿道功能障碍 (UUTD) 风险. 一个用于膀细分和UUTD风险识别的自动化系统比传统方法表现优越.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医疗成像医学成像
- 机器学习 机器学习
背景情况:
- 神经性膀患者经常面临上游泌尿道功能障碍 (UUTD) 的风险.
- 准确的UUTD风险评估对于及时干预至关重要.
- 当前的方法可能缺乏客观性和效率.
研究的目的:
- 分析膀形态特征,用于UUTD风险预测.
- 开发一个完全端到端 (E2E) 的自动化算法,用于膀细分和UUTD风险识别.
主要方法:
- 对604名神经性膀患者进行视频尿动力学 (VUDS) 的回顾性分析.
- 从手动和自动细分的膀感兴趣区域 (ROI) 提取36个形态特征 (形状,LoG图谱,分形特征).
- 开发和评估机器学习模型 (如SVM),使用选定的功能和FCN-ResNet101进行自动细分.
主要成果:
- 28个形态特征在膀等级之间有显著差异,形状_周周_面_比率是UUTD的一个关键预测指标 (AUC=0.722).
- 该SVM模型实现了高性能 (AUC=0.860训练,0.830测试),优于单个特征.
- 自动细分 (Dice=0.9848,mIoU=0.9705) 与手动细分 (r>0.90) 有很强的相关性,使得E2E方法具有可比的ML模型性能 (AUC=0.843训练,0.815测试).
结论:
- 膀形态特征是UUTD的强有力的预测因素.
- 开发的E2E自动化模型为早期UUTD风险评估提供了定量和客观的工具,其性能优于传统的临床参数.
- 建议在大型多中心前性研究中进一步验证,以确认临床适用性.
相关概念视频
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
1.4K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.4K
01:23Urinary Bladder
3.2K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.2K
01:22Imaging Studies VI: Voiding Cystourethrography and Cystography
1.3K
Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
1.3K
01:19Urodynamic Studies: Uroflowmetry
3.6K
Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
3.6K