左和右结肠癌之间的免疫微环境差异:CASC15+KLK6+上皮亚群与T细胞和巨细胞的动态相互作用
Yibin Zhao1, Hao Liu2,3, Yu Wang1
1Department of Colorectal Surgery, Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
International journal of surgery (London, England)
|September 11, 2025
概括
右侧结肠癌 (RCC) 具有免疫抑制的微环境,其中包括耗尽的T细胞和重新编程的乳腺细胞. 在RCC中,恶性上皮细胞亚群与生存率差相关,这表明了新的治疗点.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 右侧 (RCC) 和左侧结直肠癌 (LCC) 有不同的临床和分子特征.
- RCC和LCC之间的免疫微环境差异尚未得到充分理解.
研究的目的:
- 为了研究与左侧结肠癌 (LCC) 相比,右侧结肠癌 (RCC) 的免疫微环境.
- 在RCC中识别不同的细胞亚群和细胞间通信网络.
主要方法:
- 在6个结直肠瘤 (3个LCC,3个RCC) 上进行单细胞RNA测序.
- 在70名患者身上进行免疫光验证.
- 分析细胞异质性,伪时间轨迹,途径丰富和细胞间通信.
主要成果:
- 与LCC相比,RCC表现出消耗CD8+ T细胞的增加和激活CD8+ T细胞的减少.
- 脊髓癌显示杆细胞种群发生变化 (TNF+减少,VEGFA+增加) 和明显的恶性CASC15+KLK6+上皮细胞亚种群.
- 在RCC中观察到通过MIF和CD99途径增强的细胞间通信,与患者的生存率差相关.
结论:
- RCC具有一种免疫抑制的利基,其特点是T细胞耗尽,巨细胞重编程和特定的恶性上皮细胞亚群.
- 准MIF和CD99信号通路为右侧结肠癌提供了潜在的治疗策略.
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