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Updated: Jan 6, 2026

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Human Blastocyst Biopsy and Vitrification
Published on: July 26, 2019
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内细胞质量等级和早期爆发与欧胚胎妊娠结果有关
Yuqi Bian1, Sharon H Zhao2, Maxwell Edwin Shramuk3
1Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL, 60611, USA.
Reproductive sciences (Thousand Oaks, Calif.)
|September 11, 2025
概括
活产率更高,在早期的胚胎发育和更好的内部细胞质量质量在euploid胚胎. 在这项研究中,胚胎的性别和性别选择并没有显著影响活产生的结果.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精 (IVF)
背景情况:
- 评估影响euploid胚胎移植后活产的因素对于优化试管婴儿成功至关重要.
- 细胞内部质量 (ICM) 和肌皮质量 (TE) 是胚胎生存能力的关键指标.
- 了解爆发时间和胚胎性别在活产结果中的作用,对于临床决策至关重要.
研究的目的:
- 评估爆发时间,ICM/TE质量,胚胎性别和胚胎性别选择与欧类胚胎活产率之间的关联.
- 确定胚胎特征,可以预测冷胚胎移植 (FET) 后成功怀孕的结果.
- 为了确定胚胎的性别或性别选择是否影响欧类胚胎中活产率.
主要方法:
- 从2020年到2021年,对768个euploid冷胚胎移植周期进行了回顾性队列分析.
- 在玻璃化之前,胚胎被分类为ICM和TE质量.
- 混合效应多变量逻辑回归被用来评估活产和患者/胚胎特征之间的关联.
主要成果:
- 活产发生在52.6%的周期中.
- 与第5天 (aOR 0.81) 相比,6-7天的玻璃化与较低的活产几率有关.
- 与质量1 (aOR 0.75) 相比,ICM质量较低的胚胎的活产几率明显较低.
- 胚胎性别和胚胎性别选择与活产几率没有显著关联.
结论:
- 优先考虑早期爆发 (5日) 和优质ICM质量的胚胎可能会增加活产的概率.
- 热囊细胞质量,胚胎性别和胚胎性别选择在这个队列中没有显示出与活产几率的显著关联.
- 虽然胚胎的性别和性别选择在统计学上并不显著,但仍可能影响胚胎移植的临床决策.
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