在台湾儿童中,局部类药物处方的眼睛风险
Yao-Lin Liu1,2, Jin-Yu Tsai3, Kai-Yen Chiu1
1Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
JAMA ophthalmology
|September 11, 2025
概括
在儿童中使用阿特罗平并没有增加白内障,绿内障或黄内障的风险. 然而,长期在三年内处方阿特罗宾显示,在近视控制中,眼部并发症的风险可能增加.
科学领域:
- 眼科和公共卫生研究 眼科和公共卫生研究
- 儿科眼科护理和近视管理
背景情况:
- 近视是一个重要的全球健康问题,高近视会增加严重眼部并发症的风险.
- 由于结果不确定,常见的近视控制治疗方法阿特罗宾的长期安全性需要进一步调查.
研究的目的:
- 评估与对台湾儿童近视控制的阿特罗宾处方相关的眼睛风险.
- 为了评估白内障,绿内障和黄内障的发病率与小儿近视症中使用阿特罗宾的关系.
主要方法:
- 使用台湾国家健康保险研究数据库 (2000-2021) 进行回顾性,基于人口的队列研究.
- 包括新近视诊断的8-15岁儿童和匹配的非近视对照.
- 分析了按累积持续时间和剂量分类的阿特罗宾处方数据,并对患者进行至少5年的随访.
主要成果:
- 与非近视对照相比,近视儿童的眼部并发症发生率更高.
- 在近视使用者和非使用者之间,没有发现眼部并发症率的显著差异.
- 在超过三年的阿特罗平处方时,观察到眼部并发症的风险增加,但在高近视病例中没有.
结论:
- 对儿童近视控制的阿特罗平处方与白内障,绿内障或黄内障的风险增加没有直接关联.
- 研究结果表明,需要权衡阿特罗宾的益处和风险,特别是在长期治疗期间.
- 该研究强调了推断因果关系的局限性,并强调需要对阿特罗宾的长期安全性概况进行进一步研究.
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