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Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers
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光敏分子子调节Taspase 1活动

Antonio L Figueroa Bietti1, Alisa-Maite A Kauth2, Katrin Hommel3

  • 1Institute of Organic Chemistry I, Biosupramolecular Chemistry, University of Duisburg-Essen Universitätsstrasse 7 45141 Essen Germany thomas.schrader@uni-due.de.

RSC chemical biology
|September 11, 2025
PubMed
概括

研究人员开发了光敏分子子来控制Taspase 1活动. 该系统提供精确的,可逆调节蛋白酶功能,有助于理解胚胎发生和瘤进展.

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相关概念视频

Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.