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一次或多次注射甲型玻尿素毒素对三角神经疼痛的有效性

Ying-Ying Xu¹, Cheng-Wei Guo¹, He-Jing Chen¹

¹Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Frontiers in neurology

|September 11, 2025

概括

毒素A型 (BTX-A) 有效治疗三角神经疼痛 (TN). 虽然BTX-A在继续治疗的患者中仍然有效,但随着多次治疗,其有效性略有下降.

科学领域:

神经学神经学
药理学药理学是指药理学的学科.

背景情况:

甲型玻尿素毒素 (BTX-A) 是三角神经疼痛 (TN) 的已知治疗方法.
这项研究评估了BTX-A在接受持续治疗的TN患者的持续疗效和安全性.

研究的目的:

评估BTX-A注射在选择继续BTX-A治疗的三角神经疼痛患者的治疗效果和安全性.
为了比较初始BTX-A治疗与后续治疗在三角神经疼痛患者中的有效性.

主要方法:

对30名三角神经疼痛患者的医疗记录的回顾性审查.
单个医生通过皮下和/或粘膜下给药BTX-A.
疼痛严重程度通过视觉模拟尺度 (VAS) 评估,整体反应通过治疗前和治疗后4周的患者全球变化印象 (PGIC) 评估.

主要成果:

在第一次BTX-A治疗后,观察到VAS得分显著下降 (VAS中位数从8到3,P<0.001).
第一次治疗与多次治疗组的最后一次治疗相比,显示出明显更好的VAS改善 (P = 0.024).
在第一次和最后一次治疗之间PGIC分布没有发现显著差异 (P = 0.070).

结论:

在接受多种治疗的三角神经疼痛患者中,BTX-A 显示了持续的有效性.
在多次治疗后,BTX-A的有效性略有下降.
影响持续BTX-A治疗的因素包括患者年龄和初始治疗反应.

关键词:

一种类型A的肉毒毒素毒素.有效性评估的有效性评估.多种治疗,多种治疗.重复注射的重复注射是非常重要的.三胞胎神经疼痛三胞胎神经疼痛

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