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针对急性中期风险肺栓塞的新型吸血血栓切除和血液再注射系统:AVENTUS试验结果
Saher Sabri1, Samuel Horr2, Brian Stegman3
1Divison of Interventional Radiology, MedStar Georgetown University Hospital, Washington, DC.
Journal of the Society for Cardiovascular Angiography & Interventions
|September 11, 2025
概括
使用AVENTUS系统的机械血栓切除术有效治疗急性中等风险肺栓塞 (PE). 这种手术显著降低了凝块负担,并改善了心脏功能,血液损失最小,没有重大不良事件.
科学领域:
- 心脏病学 心脏病学
- 干预性放射学 干预性放射学
- 肺部医学 肺部医学
背景情况:
- 机械血栓切除术是急性中等风险肺栓塞 (PE) 的主要治疗方法.
- 透皮机械吸血血栓切除术与自身血液再注射是一种新兴的治疗方法.
- 阿文图斯血栓切除系统代表了PE干预的下一代技术.
研究的目的:
- 评估AVENTUS血栓切除系统的安全性和有效性.
- 评估急性中期风险PE患者的结果.
- 为了确定对右心室功能,凝块负担和患者生活质量的影响.
主要方法:
- 前性,多中心,单臂研究.
- 招募了120名急性中期风险PE患者 (症状≤14天).
- 48小时后评估初级疗效 (RV/LV比率) 和安全性 (主要不良事件);30天后评估功能状态和生活质量.
主要成果:
- 在48小时内,RV/LV直径比 (P < .0001) 和凝块负担 (35.9%,P < .0001) 显著减少.
- 平均血液损失为49.6毫升;不需要输血.
- 30天后,改善了6分钟的步行距离 (132.9m,P < .0001) 和PE特定的生活质量 (25.3分,P < .0001).
结论:
- 使用AVENTUS系统进行血栓切除术对于急性中等风险PE是安全有效的.
- 这种手术改善了右心室的功能,并减少了凝块负担.
- 在手术后观察到最少的血液损失和显著的功能改善.
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