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在肝脑轴障碍中调节核因子红色素2相关因子2和血红氧酶-1的核因子
Yi-Ming Zhang1, Zhi-Gang Zhang2
1Gastroenterology Clinic Ward, First Department of The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
World journal of psychiatry
|September 11, 2025
概括
天然草药化合物激活核素红色素2相关因子2 (Nrf2) /血氧酶-1 (HO-1) 途径,通过减少氧化应激和炎症,为各种肝脏疾病和肝脏脑病症提供有前途的治疗策略.
科学领域:
- 肝病学和药理学 肝病学和药理学
- 神经科学是一个神经科学.
- 自然产品化学 自然产品化学
背景情况:
- 世界上有数以百万计的人患有肝脏疾病,如NAFLD,酒精损伤,病毒性肝炎,纤维化,肝硬化和HCC,通常由肝脏脑病变复杂化.
- 病变发生包括氧化应激,炎症,线粒体功能障碍和免疫失调,导致肝脏脑病变的认知和情绪障碍.
- 核因子红色素2相关因子2 (Nrf2) /血氧酶-1 (HO-1) 途径是关键的抗氧化防御,Nrf2调节保护性酶,HO-1提供抗炎,抗缩和抗纤维效应.
研究的目的:
- 探索天然草本单体作为Nrf2/HO-1通路激活剂的潜力,用于治疗肝脏疾病和肝脏脑病.
- 突出这些天然化合物的多目标行动,低毒性和传统使用.
- 审查特定的草本单体及其对各种肝脏疾病及其相关神经精神症状的疗效.
主要方法:
- 对针对Nrf2/HO-1通路的天然草本单体的科学文献的综述.
- 在不同肝病模型中分析特定化合物的作用机制,如贝卡林,黄素,二米里塞丁和安德罗格拉福利德.
- 检查对肝功能障碍和神经精神疾病症状的影响.
主要成果:
- 草本单体在各种肝脏疾病中表现出有效性:贝卡林治疗脂肪肝,库尔库明治疗酒精性肝病,二米里塞丁治疗药物诱导的肝损伤,安德罗格拉福利德治疗病毒性肝炎.
- 化合物通过调节星状细胞激活来抑制肝纤维化.
- 这些天然药物通过激活Nrf2/HO-1通路来缓解肝功能障碍和神经精神症状.
结论:
- 针对Nrf2/HO-1通路的天然草本单体代表了肝脏疾病和肝脏脑病的有前途的治疗途径.
- 这些化合物具有优势,包括多目标效应和低毒性.
- 需要进一步的研究来应对诸如低生物可用性等挑战,以获得成功的临床应用.
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