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在性别不同的青少年中,患有多囊卵巢综合征的严重过度雄激素主义
Derek Schneider1, Kevin Scully1,2, Jose Bernardo Quintos1,2
1Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
JCEM case reports
|September 11, 2025
概括
患有多囊性卵巢综合征 (PCOS) 的青少年严重的过度雄激素化与男性性别认同有关. 治疗使丸激素水平正常化,并将性别认同转变为女性.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 性别认同研究 性别认同研究
背景情况:
- 性别认同的发展受到社会,心理和生物因素的影响.
- 对雄激素的暴露可能有助于男性的性别认同,正如有关性发育障碍的研究所表明的那样.
研究的目的:
- 描述由于多囊性卵巢综合征 (PCOS) 导致的严重高雄性和雄性化的案例,在一个探索性别认同的青少年中.
- 为了调查这个患者的雄激素水平和性别认同之间的关系.
- 突出性别多样性青少年PCOS的诊断和管理.
主要方法:
- 一个在出生时呈现严重高雄性特征的青少年女性的案例报告.
- 激素评估,包括总水平.
- 通过释放性荷尔蒙 (GnRH) 的类似疗法进行治疗.
- 监测与荷尔蒙变化有关的性别认同.
主要成果:
- 这位患者呈现出严重的高雄激素 (总337 ng/dL) 和PCOS的次要病毒化.
- 最初支持男性的性别认同.
- 在GnRH模拟疗法将丸激素水平正常化至女性 cisgender 范围后,患者认可了女性的性别认同.
结论:
- 这个案例说明了PCOS中雄激素过量的潜在范围.
- 它证明了荷尔蒙波动对青少年性别认同的影响.
- 强调在性别多元的青年中诊断和治疗PCOS的重要性.
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