饮食炎症指数与不孕症之间的关联:系统性审查和元分析
Yasamin Zahedi1, Shayan Bonyanpour1, Seyed Danial Alizadeh2
1Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Frontiers in nutrition
|September 11, 2025
概括
通过高的饮食炎症指数 (DII) 得分来表示的促炎症饮食与61%的不孕症风险增加有关. 针对炎症的饮食改变可能有助于不孕症管理.
科学领域:
- 营养科学 营养科学
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 不孕症影响了人类人口的很大一部分,多因素的原因.
- 饮食模式越来越多地被认为对系统性炎症和整体健康的影响,包括生殖结果.
研究的目的:
- 系统地审查和元分析观察性研究,评估饮食炎症指数 (DII) 与人类不孕症风险之间的关联.
- 量化不同人群中饮食炎症潜力和不孕不育之间的关系.
主要方法:
- 在主要数据库 (Scopus,PubMed,Web of Science等) 中进行了全面的文献搜索. 在2025年1月之前.
- 包括9项观察性研究,涉及17711名参与者,分析了DII分数和不孕症结果.
- 用随机效应模型进行了元分析,通过I2统计评估异质性.
主要成果:
- 促炎症饮食 (最高DII四分位数) 与不孕症风险增加1.61倍显著相关 (OR: 1.61,95% CI: 1.32-1.95).
- 每个单位增加的DII与10%更高的不孕症风险相关 (OR:1.10,95%CI:1.05-1.15)
- 亚组分析表明抗炎饮食与男性不孕症之间的关联,以及伊朗和美国人群的风险增加.
结论:
- 影响炎症的饮食因素在生殖健康和不孕不育方面发挥着潜在的作用.
- 修改饮食以减少炎症可能是治疗不孕症的一个有希望的策略.
- 需要进一步的随机对照试验来确定因果关系并完善饮食干预措施.
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