运动对癌症患者和癌症幸存者的免疫系统标记物的影响:系统性审查
Estela C Oliveira1, Inês R Correia1, Ana V Bernardino1
1Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Cruz-Quebrada, Portugal.
Journal of sports science & medicine
|September 11, 2025
概括
运动干预措施,包括有氧和心灵身体类型,对癌症患者和癌症幸存者的免疫细胞标志物显示出潜在的益处. 然而,结果各不相同,需要更多高质量的研究来证实这些效应.
科学领域:
- 运动免疫学 运动免疫学
- 癌症的生存率 癌症的生存率
- 细胞免疫学 细胞免疫学
背景情况:
- 癌症治疗可以损害免疫功能.
- 运动越来越多地被探索为癌症患者和癌症幸存者的辅助疗法.
- 了解运动对免疫标记的影响对于优化支持性护理至关重要.
研究的目的:
- 系统地审查不同运动方式对癌症患者和癌症幸存者的免疫细胞标记物的影响.
- 分析随机对照试验 (RCT) 关于瘤群体运动和免疫反应的研究结果.
主要方法:
- 在PubMed,科学网,柯克兰图书馆和Scopus数据库中进行系统搜索.
- 包括评估运动干预和免疫细胞标记物的RCT.
- 使用偏差风险2 (RoB2) 工具进行方法质量评估.
主要成果:
- 其中20项研究中有8项报告了运动对免疫细胞的有益影响.
- 观察到的改善包括自然杀手 (NK) 细胞,淋巴细胞和外周血液单核细胞 (PBMC) 的增加.
- 还注意到免疫球蛋白A,白细胞和NK细胞受体表达的调节;然而,研究质量各不相同,有45%的偏差风险高.
结论:
- 有氧和心身运动可以增强癌症患者和癌症幸存者的先天和适应性免疫反应.
- 运动对免疫结局的影响在所有干预措施和研究中都不一致.
- 为了阐明癌症患者群体的最佳运动策略,需要进一步进行高质量的研究,使用多种运动方案.
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