相关实验视频
Updated: Jan 18, 2026

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Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
Published on: September 20, 2024
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完全甲状腺切除术后的心血管风险在患有差异化甲状腺癌的患者中,这些患者正在接受levothyroxine替代单疗法
Martina Pucci1, Marilena Calzolaio1, Francesco Ghezzi1
1Bernadette Biondi MD Division of Internal Medicine and Cardiovascular Endocrinology. Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
Frontiers in endocrinology
|September 11, 2025
概括
对差异化甲状腺癌 (DTC) 患者的长期Levothyroxine (LT4) 治疗可能会增加心血管风险. 需要仔细监测和量身定制的指南来管理DTC幸存者的风险和益处.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 在瘤学瘤学.
背景情况:
- 差异化甲状腺癌 (DTC) 一般具有良好的预后,复发率和死亡率较低.
- 目前的指导方针建议基于DTC攻击性的LT4疗法进行个性化TSH抑制.
- 没有研究评估了长期LT4治疗2016年ATA指南后的无疾病DTC患者的心血管风险.
研究的目的:
- 评估无疾病的有性DTC患者的心血管风险.
- 应用2021年欧洲心脏病学会 (ESC) 心血管风险评估指南.
- 根据2016年ATA指南,分析长期接受LT4治疗的患者.
主要方法:
- 对102名没有疾病的DTC患者进行了回顾性分析,这些患者接受了全甲状腺切除术.
- 纳入标准:没有先前的重大心血管事件,长期的LT4治疗2016年后的ATA指南.
- 使用ESC 2021 SCORE2,SCORE2-OP和SCORE2-糖尿病评分系统评估心血管风险.
主要成果:
- 在102名患者中,有14名患者在平均12.79年的随访期间经历了重大心血管不良事件 (MACE).
- 没有没有MACE的患者被归类为非常高的CV风险.
- 在6% (SCORE2),38.5% (SCORE2-OP) 和50% (SCORE2-糖尿病) 的患者中观察到高心血管风险.
结论:
- 对DTC患者的长期随访需要勤奋地进行心血管监测.
- 需要为DTC制定特定的心血管管理指南.
- 准则应平衡LT4治疗的风险/益处,并确定高风险个体进行更密切的监测.
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