多种金属暴露和估计的脉冲波速度:对美国成年人的横截面分析
Shijie Zhou1,2, Zhihao Xiao1,2, Boyu Shi1,2
1State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Frontiers in public health
|September 11, 2025
概括
接触混合金属,特别是 (Cd) 和 (Pb),与增加动脉硬度 (ePWV) 有关. 高密度脂蛋白 (HDL) 和总胆固醇 (TC) 可能会调解这种关联,突出显示潜在的心血管风险.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 动脉硬是心血管事件的一个已知的危险因素.
- 之前关于金属暴露和动脉硬性的流行病学研究缺乏确的证据.
研究的目的:
- 调查暴露于12种尿金属和动脉硬度 (ePWV) 之间的关联.
- 探索金属引起的动脉硬的潜在调解因素.
- 评估混合金属暴露对ePWV的综合影响.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) (2003-2016) 的数据.
- 采用多重线性回归,受限立方线 (RCS),中介分析,加权量子量和 (WQS) 回归和量子量g计算 (Qgcomp).
主要成果:
- 尿液中的 (Cd), (Pb), (Co) 和 (U) 与提高的EPWV有显著的关联.
- 调解分析表明高密度脂蛋白 (HDL) 和总胆固醇 (TC) 起作用.
- WQS和Qgcomp的分析证实了混合金属暴露与ePWV之间的积极关联,其中Cd和Pb是主要贡献者.
结论:
- 混合金属暴露与高动脉硬度 (ePWV) 之间存在显著的关联.
- (Cd) 和 (Pb) 被确定为增加ePWV的主要风险因素.
- HDL和TC可能会调解混合金属对动脉硬度的影响.
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