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婴儿对常见食物过敏原的敏感性与食物蛋白诱导的过敏性肠道炎:一个前性研究
Mozhgan Moghtaderi1, Sara Mostafavi1, Naser Honar2
1Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Asia Pacific allergy
|September 11, 2025
概括
婴儿的食物蛋白诱导过敏性口腔炎 (FPIAP) 通常涉及IgE对常见食物的敏感化. 通过皮肤测试进行早期识别,可以预测持续的牛奶不耐受,指导管理策略.
科学领域:
- 儿科过敏和免疫学
- 胃肠病学 胃肠病学
背景情况:
- 食物蛋白诱导的过敏性口腔炎 (FPIAP) 通常不是IgE介导的.
- 然而,在一些患有FPIAP的婴儿中观察到IgE敏感性.
研究的目的:
- 通过皮肤测试来确定患有FPIAP的婴儿对常见食品的IgE敏感性的流行率.
- 在5年的随访期内,评估牛奶耐受性发展的速度.
主要方法:
- 对2017年被诊断患有FPIAP的婴儿进行前性研究.
- 用11种常见的食物过敏原进行皮肤刺伤测试.
- 随访5年,通过摄入牛奶来证实耐受性.
主要成果:
- 在完成研究的81名婴儿中,32%的婴儿对至少一种食物过敏原表现出敏感性.
- 牛奶和蛋是最常见的过敏原 (13.6%).
- 到1岁时,牛奶耐受性在45.7%的人群中发展,到4岁时达到96.3%. 敏感度与耐受性开始相关 (P < 0.001).
结论:
- 建议在FPIAP婴儿中进行常见食物过敏原的皮肤测试.
- IgE敏感性可能表明持久性牛奶不耐受性更高的可能性.
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