术前计算机断层扫描-泌尿学结合炎症标志物的诊断价值,可预测发生淋巴结转移的急性囊切除术患者的淋巴结转移
Kun Yang1,2, Mingxin Jiang1,2, Tianyu Zhang1,2
1Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Bladder (San Francisco, Calif.)
|September 11, 2025
概括
结合CTU淋巴结大小和MLR和PLR等炎症标志物的新型淋巴图,可以准确预测膀癌患者的淋巴结转移. 需要进一步验证临床使用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 淋巴结转移是膀癌的一个关键预后因素.
- 准确的预测会影响治疗决策和患者的治疗结果.
研究的目的:
- 评估骨盆淋巴结大小对CTU和激进囊切除患者淋巴结转移的炎症标志物的预测值.
- 开发淋巴结转移的预测模型.
主要方法:
- 对174名急性囊切除术患者的回顾性分析.
- 计算中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和单细胞与淋巴细胞的比率 (MLR).
- 接收器操作特征 (ROC) 曲线分析和多变量后勤回归以确定预测因素并构建模型.
主要成果:
- 临床T阶段,瘤等级,NLR,PLR,MLR和CTU淋巴结直径在转移和非转移组之间有显著差异.
- 确定了NLR (3.22),PLR (156.4) 和MLR (0.62) 的最佳截止值.
- 临床T阶段,CTU淋巴结直径,MLR和PLR是独立的预测因素,产生了一个AUC为0.847.7的模型.
结论:
- 一个整合CTU发现,临床T阶段,MLR和PLR的nomogram有效地预测了激进囊切除患者的淋巴结转移.
- 这个模型显示了改善风险分层的前景.
- 建议在临床实施之前进行多中心验证.
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