长期COVID中的神经认知轨迹:纵向分析的证据
Jacqueline H Becker1, Jia Li2, Jenny J Lin1
1Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Brain, behavior, & immunity - health
|September 11, 2025
概括
在COVID-19之后,认知功能通常会得到改善,但处理速度和执行功能在长期内仍会受到损害. 下体质指数预测长期COVID患者的认知恢复更好.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- COVID-19 (冠状病毒疾病2019) 幸存者经常报告持续的认知障碍,通常称为"大脑雾".
- 在SARS-CoV-2感染后,这些认知缺陷的长期恢复轨迹仍然不完全理解.
研究的目的:
- 在急性SARS-CoV-2感染后42个月的时间内评估认知功能变化.
- 确定与COVID-19后认知功能恢复轨迹相关的因素.
主要方法:
- 分析了1553名参与者在西奈山卫生系统后COVID-19注册表中的数据.
- 在任何严重程度的SARS-CoV-2感染后,跟随成年人的前性队列研究.
- 使用经过验证的人身测量方法评估认知功能;用于分析随时间变化和影响因素的线性混合模型.
主要成果:
- 注意力,工作记忆,处理速度,执行功能和口头学习/记忆的认知分数在COVID-19后的42个月内呈现逐步改善.
- 尽管有改进,处理速度和执行功能仍然平均低于规范平均值的标准偏差超过1个.
- 体重指数 (BMI) 低于25公斤/平方米是更大的认知评分改善的重要预测指标.
结论:
- 随着COVID-19后的认知障碍随着时间的推移而有所改善,但处理速度和执行功能的缺陷长期存在.
- 与长期COVID相关的认知健康负担是相当大的和持久的.
- 未来的研究应该专注于认知恢复的干预措施和长期COVID患者的动态风险预测模型.
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