在产前到产后阶段的介导神经发育障碍的分子特征
Sabiha Sultana Preety1, Fahim Rejanur Tasin2, Amit Sarder1
1Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, Bangladesh.
EXCLI journal
|September 11, 2025
概括
在发育过程中接触可以通过表观遗传变化损害胎儿的神经发育. 这篇评论详细介绍了的细节.
科学领域:
- 环境毒理学环境毒理学
- 发育神经生物学 发育神经生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 暴露对胎儿发育构成风险,因为它具有穿越生物障碍的能力.
- 表观遗传变化与后代的诱导的神经发育障碍有关.
- 特定的表观遗传变化,如NR3C1高甲基化和改变的胎盘miRNA表达,与认知和中枢神经系统障碍有关.
研究的目的:
- 审查发育中的胎儿中诱导的神经毒性的表观遗传机制.
- 为了追踪暴露的母亲-胎儿-新生儿旅程.
- 突出发育中的胎儿对对神经发育的不利影响的脆弱性.
主要方法:
- 这是对现有研究进行综合的叙述性综述.
- 它描述了表观遗传机制,包括DNA甲基化,miRNA表达和基因组修饰.
- 它追踪了从母亲到胎儿和新生儿的运输途径.
主要成果:
- 暴露于会诱导各种表观遗传变化,包括DNA甲基化,改变miRNA表达 (例如,miR-509-3p,miR-193-5p) 和基因素修饰.
- 这些表观遗传变化破坏了关键的发育途径,例如下丘脑-垂体-上腺轴,导致神经发育障碍.
- 可以通过母乳从母体循环转移到胎儿,然后通过母乳转移到新生儿.
结论:
- 在关键发育阶段暴露于会对胎儿神经发育造成重大风险.
- 表观遗传修饰是神经毒性作用的关键调解者.
- 了解运输和表观遗传影响对于减轻神经发育风险至关重要.
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