通过升级纳米平台进行NIR-II光控制光合作用激活,用于在急性损伤中进行向生物能疗法
Xiaojuan Hu1, Xingwen Cheng2, Liqiang Shao1
1Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014 Zhejiang, China.
Journal of medicinal chemistry
|September 11, 2025
概括
这项研究介绍了一种新的纳米平台 (UCTR),它使用近红外光为光合作用提供动力,补充细胞能量并修复急性损伤 (AKI) 中的线粒体. 这种方法通过恢复生物能量和促进管状修复来增强功能.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 脏生理学 脏生理学
背景情况:
- 急性损伤 (AKI) 涉及管损伤,线粒体功能障碍和氧化应激,造成细胞能量缺乏.
- 向药物输送到脏是具有挑战性的,因为其复杂的结构,阻碍了代谢恢复疗法.
研究的目的:
- 开发一种新的生物能纳米平台 (UCTR),用于在AKI中进行有针对性的能量补充和线粒体修复.
- 用上转化纳米粒子 (UCNP) 增强光合作用来治疗损伤的治疗干预.
主要方法:
- UCTR的制造:UCNP被封装在甲状腺膜 (TM) 中,并被脏管状上皮细胞膜 (RECM) 覆盖,用于向传递.
- NIR-II光激活:UCNP将NIR-II光转换为可见波长,在TM中驱动ATP和NADPH合成.
- 治疗机制:外源能量供应,AMPK/PGC-1α通路的激活,线粒体潜力的恢复,以及协同的抗氧化/抗炎作用.
主要成果:
- 在受伤的管中,UCTR显示有针对性的积累.
- NIR-II光照照射成功激活了光合作用ATP和NADPH合成,减轻了缺氧引起的能量赤字.
- 观察到线粒体膜潜力的恢复和 tubular 修复的加速.
结论:
- 该UCTR纳米平台有效地解决了针对性交付和代谢恢复在AKI的挑战.
- 通过恢复细胞生物能量和促进组织修复,UCTR显示出治疗损伤的巨大潜力.
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