放射治疗和免疫治疗的肌肉骨并发症
Arash Azhideh1, Sara Haseli1,2, Stephanie K Schaub3
1Department of Radiology, Division of Musculoskeletal and Intervention, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98195.
概括
放射治疗 (RT) 和免疫治疗会导致肌肉骨并发症,如骨脆弱和关节炎. 识别这些副作用对于准确的诊断和患者护理至关重要.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 类风湿病学 类风湿病学
背景情况:
- 放射治疗 (RT) 和免疫治疗是标准的癌症治疗方法.
- 这两种疗法都可能导致显著的肌肉骨并发症.
- 这些并发症可以模仿其他严重的疾病,造成诊断挑战.
研究的目的:
- 为提供从RT和免疫疗法的肌肉骨并发症的全面概述.
- 突出放射生物学的原则和不断发展的免疫疗法领域.
- 强调诊断特征,以区分这些并发症与转移或感染.
主要方法:
- 对RT的放射生物学原理的审查.
- 免疫治疗 (例如,免疫检查点抑制剂) 的免疫相关不良事件的分析.
- 临床背景和成像特征与特定并发症的相关性.
主要成果:
- 肌肉骨的并发症包括骨脆弱,骨折,骨质神经衰竭,关节炎,肌肉炎和肌病.
- RT并发症取决于剂量,分量和技术 (例如,立体体 RT,质子束疗法).
- 免疫疗法可以导致炎症性关节病,肌肉炎和肠炎,通常是血清阴性.
结论:
- 来自RT和免疫治疗的肌肉骨并发症是多样化的,可以模仿其他疾病.
- 了解特定的RT技术和免疫治疗不良事件是关键.
- 准确的诊断和管理依赖于识别临床和成像模式.
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