通过信号传输的马尔科夫模型,结构连接对大脑功能的作用
Rostam M Razban1, Anupam Banerjee1, Lilianne R Mujica-Parodi1,2
1Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook. New York, United States of America.
PloS one
|September 11, 2025
概括
大脑结构和功能由通勤时间联系在一起,这是一个测量信号传播的新型指标. 这种方法比现有的方法更好地解释大脑连接.
科学领域:
- 神经科学是一个神经科学.
- 计算生物学 计算生物学
- 网络科学 网络科学
背景情况:
- 大脑结构和功能之间的关系是神经科学的一个基本概念.
- 在人类大脑神经成像数据中观察这种结构功能联系已经证明具有挑战性.
- 现有的方法往往难以捕捉神经信号传播的复杂性.
研究的目的:
- 通过基于信号传播的新型度量来将大脑结构与功能联系起来.
- 为了测试大脑信号在大脑结构网络上以马科夫过程传播的假设.
- 为了评估通勤时间作为大脑连接的衡量标准的有效性.
主要方法:
- 利用扩散MRI绘制白质道和结构连接的地图.
- 计算通勤时间,表示一个随机步行者在大脑区域之间的平均步骤.
- 相关的通勤时间与功能性MRI连接数据来自英国生物银行和HCP年轻成年人数据集.
主要成果:
- 通勤时间与功能连接有显著的负相关性 (r ≈ -0.25).
- 当比较通勤时间和功能连接 (r ≈ -0.34) 的主要贡献时,相关性得到改善.
- 与功能连接的主要模式相比,通勤时间的表现优于其他通信措施 (搜索信息,可通讯性) 的33%,高达5倍.
结论:
- 通勤时间是通过计算间接连接来了解大脑功能的一个有价值的指标.
- 这项研究支持信号随机穿越大脑结构网络的模型.
- 这种方法提供了一种更强大的方法来链接结构性和功能性大脑连接体.
相关概念视频
Neuronal Communication
3.1K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
3.1K
Brain Imaging
670
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
670
Functional Brain Systems: Reticular Formation
4.4K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
4.4K
Neurons as Communicators of the Brain
3.0K
Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
Cell Body
The cell body, also known...
3.0K
Organization of the Brain
2.4K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.4K


