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Updated: Jan 18, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
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对于降解RAS GTPases的LZTR1识别的结构基础

Srisathiyanarayanan Dharmaiah1, Daniel A Bonsor1, Stephanie P Mo2

  • 1National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Science (New York, N.Y.)
|September 11, 2025
PubMed
概括

氨酸类似的转录调节剂1 (LZTR1) 针对RAS GTPases进行降解. 了解LZTR1的RAS结合机制揭示了RAS信号和KRAS驱动癌症的潜在治疗策略.

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