对于妇科恶性瘤的骨盆排泄后的并发症和复发:来自COREPEX研究的生存分析
Nicolò Bizzarri1, Denis Querleu, Giulio Ricotta
1UOC Ginecologia Oncologica, Dipartimento di Scienze Della Salute Della Donna, Del Bambino e di Sanità Pubblica, and the Biostatistics Unit, Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, the Unit of Gynecologic Oncology, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples, and the Department of Medicine, University of Udine, and the Clinic of Obstetrics and Gynecology, "Santa Maria della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy; the Department of Surgical Oncology, Department of Surgical Oncology and INSERM CRCT Team 19, Oncogenesis of Sarcomas, and the Department of Surgical Oncology and INSERM CRCT Team 1, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France; the First Obstetrics and Gynecology Clinic, "G. E. Palade" University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania; the Department of Gynecologic Oncology, La Fe University and Polytechnic Hospital, the POG Department University of Valencia, and the CEU Cardenal Herrera University, Valencia, Gynecologic Oncology, Universidad de Navarra, Pamplona, and the Gynecologic Oncology Unit, La Paz University Hospital, Madrid, Spain; the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Başkent University Hospital, Ankara, and the Department of Obstetrics and Gynecology, Koc University School of Medicine and VKV American Hospital, and the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey; the Department of Gynaecology, Obstetrics and Neonatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic; the Department of Gynaecology, National Institute of Oncology, Budapest, Hungary; the Department of Pelvic Cancer and Women's and Children's Health, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden; the Department of Gynecology with Center for Oncological Surgery, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, Berlin, and the Department of Gynecology and Obstetrics, Florence-Nightingale-Hospital, Düsseldorf, Germany; the Northern Gynaecological Oncology Centre (NGOC), Queen Elizabeth Hospital, Gateshead, United Kingdom; the National Cancer Institute, Kiev, Ukraine; the NN Alexandrov National Cancer Centre of Belarus, Minsk, Belarus; the Department of Gastrointestinal Surgery, University Hospital Ghent, and Human Structure and Repair, Ghent University, Ghent, Belgium; and the National Cancer Institute, Bratislava, Slovakia.
这项研究确定了影响妇科癌症骨盆排骨后生存的关键因素. 一个新的预后得分有助于预测复发风险,并指导患者咨询和监测策略.
科学领域:
- 妇科瘤学 妇科瘤学
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 盆腔排骨是一种复杂的手术程序,用于晚期妇科癌症.
- 了解预后因素对于优化患者的治疗结果和管理策略至关重要.
研究的目的:
- 为了评估5年无病存活率 (DFS) 和骨盆排骨后的整体存活率 (OS).
- 确定复发和死亡的风险因素,并制定预后得分.
主要方法:
- 这是一项回顾性,多中心的国际研究,对862名为宫癌,阴道癌,阴道癌或子宫内膜癌而接受盆腔排气的患者进行了研究.
- 收集了关于手术结果,复发模式和生存率的数据.
- 一个多变量预后得分是基于识别的独立因素开发的.
主要成果:
- 积极的外科边缘,淋巴血管空间入侵和全骨盆排骨与更糟糕的DFS和OS有关.
- 淋巴切除术与改善的DFS有关.
- 预后得分确定了四个风险组,其5年DFS和OS率显著不同.
- 副大动脉淋巴结转移与更差的生存结果相关.
结论:
- 在接受盆腔排泄的患者中,确定了DFS和OS的独立预后因素.
- 一个新的多变量预后得分可以将患者分为不同的风险组.
- 这一分数有助于患者咨询,监测计划和未来的研究工作.


