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Updated: Jan 18, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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虚拟化合物查发现多巴胺D1受体偏倚的体调节器

Yang Zhou1, William C Wetsel2,3, Steven H Olson4

  • 1Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, United States.

Journal of chemical information and modeling
|September 11, 2025
PubMed
概括

研究人员开发了一个新的药物选平台,以找到更安全的多巴胺D1受体 (D1R) 治疗帕金森病 (PD). 他们确定了一种主要化合物DUSBI-A3,可选择性地向D1R,为改善PD治疗提供了更少副作用的潜力.

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