在怀孕早期,母亲的肠道微生物组预测了早产
Zelei Miao1, Shijia Hu1, Ping Wu2
1Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China; Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China.
Cell host & microbe
|September 11, 2025
概括
母亲肠道微生物组分析确定了微生物风险评分 (MRS) 以预测孕妇早产风险. 克洛斯特里无菌 (Clostridium innocuum) 显示出显著的关联,为针对微生物群的干预提供了潜力.
科学领域:
- 微生物组研究的研究.
- 孕产妇和胎儿的医学
- 遗传学 遗传学 是一个
背景情况:
- 早产是导致婴儿死亡的主要原因,缺乏可靠的早期预测生物标志物.
- 母亲肠道微生物组在怀孕结果中的作用需要进一步阐明.
研究的目的:
- 为了识别与早产风险相关的母体肠道微生物特征.
- 开发微生物风险评分 (MRS) 用于早期预测早产.
- 研究特定微生物在早产中发挥的功能作用.
主要方法:
- 5,313名中国怀孕妇女的母体肠道微生物组在两个队列中的表征.
- 基于已识别的微生物属和物种,开发和验证微生物风险评分 (MRS).
- 分析宿主多基因易感性及其与微生物因素的相互作用.
- 对Clostridium innocuum及其17β-雌激醇降解基因的功能分析.
主要成果:
- 11个属和1个物种与早期怀孕中早产有关.
- 微生物风险评分 (MRS) 通过妊娠时间和早产风险有效地隔离女性.
- MRS证明了与宿主多基因易感性相互作用,以放大早产风险.
- 克洛斯特无菌被确定为一个关键的微生物特征,通过基因k141_29441_57表现出17β-雌激醇降解活性,在早产病例中得到丰富.
结论:
- 孕产妇肠道微生物组概况和MRS为预测早产早产风险提供了一个有希望的方法.
- 无害菌及其降解雌激素的活动代表了一种新的微生物标,用于理解和潜在地减轻早产.
- 这些发现支持开发针对微生物组的预测和治疗策略,以应对不良妊娠结果.
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