微量营养素在现代人类进化中的全球影响
Jasmin Rees1, Sergi Castellano2, Aida M Andrés3
1Great Ormond Street Institute of Child Health, University College London, London, UK; UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK.
微量营养素缺乏在全球范围内显著影响了人类进化,推动了基因的局部适应. 这凸显了面临持续土壤枯竭和气候变化的人口的潜在风险.
科学领域:
- 人类进化人类进化
- 营养基因组学 营养基因组学
- 人口遗传学 人口遗传学
背景情况:
- 微量营养素对人类健康至关重要,缺乏微量营养素会造成生长和疾病的风险.
- 历史上和现在,广泛的微量营养素缺乏影响全球数十亿人.
- 微量营养素在人类适应和进化中的作用尚未完全理解.
研究的目的:
- 研究与13种微量营养素相关的基因中积极选择的遗传特征.
- 评估微量营养素驱动的适应在不同的人群中的影响.
主要方法:
- 对276个与13种必需微量营养素相关联的基因进行分析.
- 全球人类人口中快速局部适应特征的识别.
- 在各种地理和时间尺度上检测寡原性阳性选择.
主要成果:
- 确定了微量营养素相关基因快速局部适应的已知和新鲜实例.
- 在全球人口中观察到广泛的适应特征.
- 发现了与地质和微量营养素缺乏相关的选择证据.
结论:
- 微量营养素缺乏在人类进化中发挥的作用比以前被认为的要大得多.
- 持续的环境变化可能会增加敏感人群中微量营养素相关健康问题的风险.
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