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巴齐布申通过准粉样蛋白病理,神经炎症和细胞衰老来改善5×FAD小鼠的认知功能障碍

Huixian Huang¹, Wensi Lu², Yusi Huang²

¹Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Centre for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Provincial Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China; Center of clinical laboratory, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518001, China.

Journal of ethnopharmacology

|September 11, 2025

概括

巴齐布申 (BZBS) 改善了小鼠的认知能力,并减少了老年痴呆症 (AD) 病理. 这种传统中医药配方显示出潜在的预防和治疗阿尔茨海默病的潜力.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

巴西布申 (BZBS) 是一种传统中医 (TCM) 配方,有可能导致与年龄相关的认知衰退.
它在阿尔茨海默病 (AD) 中的疗效和机制尚不清楚.

研究的目的:

为了评估BZBS在5×FAD转基因小鼠中的治疗效果,一个AD模型.
阐明BZBS在AD中的作用的基本机制.

主要方法:

5×FAD小鼠接受了BZBS治疗,并使用Y-迷宫和莫里斯水迷宫评估认知表现.
粉样β (Aβ) 斑块积累,APP-CTF和BACE1水平,炎症和细胞衰老标志物被分析使用提奥夫拉S染色,免疫光,西部斑点和qPCR.

主要成果:

在4个月大的小鼠中,BZBS治疗改善了学习和记忆,降低了Aβ沉积,APP-CTF和BACE1水平.
BZBS降低了炎症标志物 (IL-1α,IL-6,NF-κB) 和海马中的微质激活.
在6个月大小的小鼠中,BZBS降低了细胞衰老标志物 (p16,p21,SA-β-gal) 的调控,即使在疾病发作后给予,也显示出好处.

结论:

在AD的小鼠模型中,BZBS表现出显著的治疗效果,改善认知和减少关键的病理特征.
BZBS有效地减少了Aβ沉积,神经炎症和细胞衰老.
作为阿尔茨海默病的预防和疾病修饰疗法,BZBS显示出前景.

关键词:

阿尔茨海默病的疾病阿尔茨海默病的疾病.粉样蛋白-β 是一种巴兹布申布森是一个很棒的球队.认知功能认知功能神经炎症是一种神经炎症.

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