左心室全球纵向应变与住院老年人的体力表现有关
Yu Song1, Pan Liu1, Yumeng Chen1
1Department of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Experimental gerontology
|September 11, 2025
概括
通过全球纵向应变 (GLS) 测量心脏功能受损与老年人身体表现下降有关,老年人具有保存的射出分数. 这一发现凸显了GLS作为该人口中移动性问题的潜在生物标志物.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 心声回声图 (Echocardiography) 是一种心声回声图.
背景情况:
- 老年人的体力表现低下与不良的临床结果有关.
- 全球纵向应变 (GLS) 是一种敏感的心脏功能指标,可能比标准心声回声测量更具预测性.
- 老年人GLS与体力表现之间的关联尚未得到充分证实.
研究的目的:
- 为了研究全球纵向应变 (GLS) 和住院老年人的身体表现之间的关系,保留了喷射分数.
主要方法:
- 274名住院患者 (>60岁,LVEF ≥50%) 接受了斑点跟踪心声扫描以测量GLS.
- 使用短物理性能电池 (SPPB) 评估身体表现,根据运动限制 (SPPB ≤9) 与正常运动 (SPPB >9) 分类参与者.
- 后勤回归,受限立方线和子组分析检查了GLS和物理性能指标之间的关联.
主要成果:
- 运动受限的患者年龄较大,GLS受损,营养不良,脆弱性较高,多种药物.
- 恶化GLS显示,移动性限制的几率逐渐增加.
- 最糟糕的GLS四分位数与最好的四分位数相比,甚至在完全调整后,移动性限制的几率明显更高 (OR4.21). 观察到GLS和SPPB,步行速度和椅子上升时间之间存在线性关联.
结论:
- 全球纵向应变 (GLS) 损伤显着与老年住院患者的低体力表现有关,这些老年患者具有保存的射出分数.
- GLS可以作为一种有价值的生物标志物,用于识别有流动性下降风险的老年人.
关键词:
脆弱性 脆弱性 脆弱性肌动脉应变菌株是什么年龄较大的成年人.短时间的物理性能电池电池.斑点跟踪回声心脏图谱 (speckle-tracking echocardiography) 是一种跟踪斑点的回声心脏图谱.更多相关视频
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
24.7K
08:17Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
15.0K
相关概念视频
01:29Heart Failure II: Pathophysiology
752
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
752
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
416
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
416