双相情感障碍患者的不良童年经历和心脏代谢风险因素
Alyna Turner1, Maya Kuperberg2, Hugh McGovern1
1Deakin University, School of Medicine, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Victoria, Australia.
Journal of affective disorders
|September 11, 2025
概括
双相情感障碍患者的不良童年经历 (ACE) 并没有显著影响基线心脏代谢风险. 然而,在24周的治疗期间,这些患者在代谢综合征和心血管标志物中表现出更大的改善.
科学领域:
- 精神病学和心血管健康 精神病学和心血管健康
- 心理健康和代谢综合征
背景情况:
- 双极性障碍 (BD) 与较高的心血管疾病 (CVD) 死亡率,代谢综合征 (MetS) 和肥胖有关.
- 儿童不良经历 (ACE) 是这些风险的潜在贡献者,但研究结果不一致.
研究的目的:
- 研究双相情感障碍患者中ACE和心脏代谢风险标志物之间的关联.
- 为了检查这些关联在24周的药理治疗 (或氨酸) 期间如何变化.
主要方法:
- 分析了482名患有双相情感障碍的参与者的数据.
- 在基线和24周治疗后,有和没有ACE病史的参与者之间的心脏代谢标志物的比较.
- 敏感性分析,以探索特定的ACE类型对治疗结果的影响.
主要成果:
- 在基线,患有ACE的参与者身体质量指数 (BMI) 较高,但心脏代谢标记与没有ACE的参与者相比相似.
- 在24周的治疗期间,患有ACE的参与者在连续代谢综合征得分 (cMetS),腰围,高密度胆固醇和透气血压方面表现出更大的改善.
- 特定的ACE类型与差异性改善有关:性虐待与HDL,情绪虐待与透缩血压,情绪/身体虐待与腰围和cMetS.
结论:
- 患有双相情感障碍和ACE病史的个人从精神病治疗中获得了显著的心血管健康益处,与没有ACE的人相比或超过.
- 精神病治疗可能提供一个独特的机会,以减轻与双相情感障碍中ACE相关的心脏代谢风险.
- 需要进一步的研究来探索长期影响,特定的ACE类型影响以及这些治疗益处背后的机制.
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