Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Human Genetics01:28

Human Genetics

1.5K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.5K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

792
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
792
Depression: Overview01:18

Depression: Overview

800
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
800
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

451
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
451
Teratogenicity01:07

Teratogenicity

4.0K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.0K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

509
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
509

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Intracranial mapping identifies high-frequency cortical dynamics underlying visual discomfort.

NeuroImage·2026
Same author

An evaluation of the clinician-facing research dashboards from the Toronto Adolescent and Youth (TAY) Cohort Study in mental health care.

PLOS mental health·2026
Same author

Peripheral GABAergic markers in late-life depression: Links to clinical outcomes.

Brain research·2026
Same author

Resting-state EEG alpha-BOLD coupling spatially follows cortical cell-type and receptor gradients.

bioRxiv : the preprint server for biology·2026
Same author

Cohort profile: The Czech Health, Alcohol and Psychosocial factors In Eastern Europe study (HAPIEE-CZ).

Research square·2026
Same author

Parental alcohol supply in early childhood and adolescent drinking: Evidence from a prospective cohort - ADDENDUM.

European psychiatry : the journal of the Association of European Psychiatrists·2026

相关实验视频

Updated: Jan 18, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

3.5K

母亲产前抑郁症和子女偏离正常大脑发育的偏差

Klara Mareckova1, Radek Marecek2, Jana Klanova3

  • 1Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; First Department of Neurology, Faculty of Medicine, Masaryk University, and St Anne's University Hospital, Brno, Czech Republic.

Biological psychiatry. Cognitive neuroscience and neuroimaging
|September 11, 2025
PubMed
概括

母亲产前抑郁症 (MAD) 与后代的乳头和核发育的改变有关. 这些大脑区域的差异持续到成年期,可能会增加抑郁症的风险.

关键词:
纵向研究是一项纵向研究.母亲产前抑郁症 母亲产前抑郁症规范性大脑发育 规范性大脑发育核积累的中心 (nucleus accumbens).泰拉姆斯 泰拉姆斯 泰拉姆斯年轻人的成年期.

更多相关视频

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model
04:20

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

2.4K
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

1.0K

相关实验视频

Last Updated: Jan 18, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
06:39

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

3.5K
Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model
04:20

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

2.4K
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

1.0K

科学领域:

  • 神经科学是一个神经科学.
  • 发展心理学 发展心理学
  • 精神病学是一个精神病学.

背景情况:

  • 怀孕期间母亲的心理健康对胎儿大脑发育至关重要.
  • 产前暴露于母亲抑郁症可能会影响后代的大脑衰老.
  • 孕产妇产前抑郁症 (MAD) 对后代大脑发育的长期区域特异性影响尚未完全理解.

研究的目的:

  • 调查MAD是否预测后代皮层厚度,表面积和皮层下体积的特定区域偏差.
  • 为了确定这些特定区域的偏差是否在生命的第三十年内保持稳定.

主要方法:

  • 利用来自产前出生队列的神经成像数据,并在年轻成年期进行了两次随访.
  • 采用了CentileBrain模型,分析了3岁至90岁个体的37,407次MRI扫描.
  • 评估了MAD与20多岁早期和20多岁末期后代规范性大脑发育偏差之间的关联.

主要成果:

  • MAD预测了体和核发育的偏差,但没有预测其他皮质下体积,表面积或皮质厚度.
  • 暴露于更高MAD的后代在20多岁早期和20多岁后期具有更小的乳头和核.
  • 性差异出现了:暴露于更大的MAD的男性在20多岁后期表现出更大的核,但没有thalamus偏差.

结论:

  • 与MAD相关的乳头和腹核的发育变化可能会增加患重度抑郁症的风险.
  • thalamus 涉及抑郁症的发病,而核 accumbens 对于奖励和动机至关重要.
  • 这些发现强调了产前母亲抑郁症对特定大脑结构和潜在心理健康结果的持久影响.