预测人类帕雷科病毒脑膜大脑炎的严重短期神经学结果
Nisha Shah1, Aspasia Katragkou2, Olivier Fortin3,4
1University of Kansas School of Medicine-Wichita, Wichita, Kansas.
Pediatrics
|September 11, 2025
概括
人类帕雷科病毒 (PeV) 可以在婴儿中引起严重的脑膜炎 (ME),即使初始测试正常. 临床医生应在婴儿败血症中怀疑PeV,并考虑对高风险病例进行神经成像.
科学领域:
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 人类帕雷科病毒 (PeV) 是一种新兴的病原体,导致婴儿脑膜炎 (ME).
- 2022年美国爆发的疫情为研究PeV ME临床特征和严重疾病预测因素提供了机会.
研究的目的:
- 分析患有PeV ME的婴儿的临床表现.
- 确定患有PeV ME的婴儿中严重疾病和异常大脑MRI的预测因素.
主要方法:
- 对被诊断患有PeV ME的婴儿进行了多中心回顾性审查.
- 对人口统计,临床症状,实验室结果和神经影像分析.
- 后勤回归来确定复杂疾病和异常大脑MRI的预测因素.
主要成果:
- 确定了139名患有PeV ME的婴儿;中位数年龄为19天.
- 发烧很常见 (89.2%),并与较轻的疾病有关.
- 复杂的疾病 (30.2%) 与低温,昏昏欲睡,营养不良,发作,呼吸暂停以及需要通风/支持有关.
- 年轻的年龄和发作预测异常的MRI.
结论:
- 尽管没有特定的症状和正常的实验室,但PeV可以导致婴儿ME的严重发作,需要高度的临床怀疑.
- 建议在婴儿败血症工作中进行PeV测试,对高风险婴儿进行神经成像,并进行发育跟踪.
相关概念视频
01:35Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
01:25Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...