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优化低质量胚胎的冷胚胎移植:比较自然周期和激素治疗周期的结果 - - 追溯分析

Tsun-Wen Hsiao¹, Jen-Yu Wen¹, Yi-Lun Lin¹

¹Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan.

Taiwanese journal of obstetrics & gynecology

|September 11, 2025

概括

选择低质量的胚胎的自然循环冷胚胎移植 (NC-FET) 可能会提高活产率,而不是激素治疗冷胚胎移植 (HT-FET). 这项研究分析了初始FET周期中基于胚胎质量的结果.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精过程中受精.
临床胚胎学临床胚胎学

背景情况:

冷胚胎移植 (FET) 是辅助生殖技术的一个关键组成部分.
两种常见的FET协议包括自然循环FET (NC-FET) 和激素治疗FET (HT-FET).
胚胎质量是影响FET成功率的关键因素.

研究的目的:

为了比较NC-FET与HT-FET在初始FET周期中的临床结果.
调查胚胎质量对NC-FET和HT-FET结果差异的影响.
根据胚胎质量确定最佳的FET疗法.

主要方法:

对670名接受第一次FET周期的女性进行了回顾性队列研究.
对NC-FET (n=121) 和HT-FET (n=549) 组进行比较.
按胚胎质量分层 (高低) 并分析植入,怀孕,活产和流产率.

主要成果:

在NC-FET和HT-FET之间的临床结果中没有总体显著的差异.
在HT-FET中具有高质量的胚胎的患者的植入率比NC-FET (34%) 高 (45%).
与HT-FET相比,在NC-FET中具有低质量的胚胎的患者的活产率明显更高 (aOR2.57).

结论:

对于接受低质量的胚胎的患者来说,NC-FET可能是一个更有利的选择.
HT-FET可能为高质量的胚胎植入提供优势.
将FET协议定制为胚胎质量可以优化活产率.

关键词:

在冷胚胎移植过程中,冷胚胎被移植.在HT-FET中,HT-FET是最重要的.低质量的胚胎质量很差.在NC-FET中.质量差的胚胎质量差.

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