在lenvatinib加上 pembrolizumab治疗复发性子宫内膜癌的肺胸部:一个病例报告
Masahiro Taguchi1, Yoshifumi Takahashi1, Miku Nakamura1
1Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Taiwanese journal of obstetrics & gynecology
|September 11, 2025
概括
肺胸炎是伦瓦提尼布加上班布罗利祖马布 (LP) 治疗的罕见副作用. 这一案例表明肺胸炎可能发生,特别是在肺转移的子宫内膜癌患者中,但可以通过降低剂量来管理.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 肺胸炎是癌症治疗中的罕见不良事件.
- 伦瓦提尼布是一种抗血管性多动酶抑制剂,具有器官穿孔的风险.
- 子宫内膜癌的治疗可能涉及复杂的治疗方案,包括免疫疗法.
研究的目的:
- 报告在内膜腺癌治疗伦瓦提尼布加布罗利祖马布治疗期间发生的肺胸病例.
- 为了突出与联想林瓦提尼布和潘布罗利祖马布联合治疗相关的潜在不良事件.
主要方法:
- 一个63岁妇女患有晚期子宫内膜腺癌的病例报告.
- 该患者接受了多种治疗,包括手术,化疗,并最终为进展性肺部和肺转移而接受了伦瓦提尼布加 pembrolizumab (LP).
- 肺胸部的治疗包括胸腔管安置和胸,随后减少伦瓦替尼的剂量.
主要成果:
- 通过对子宫内膜癌进行LP治疗,实现了稳定的疾病.
- 患者在开始LP治疗7个月后发展出右肺肺胸部.
- 在胸管安置和胸膜切除后肺胸部消失了,并且在降低剂量重新开始使用伦瓦提尼布时没有复发.
结论:
- 肺胸炎是伦瓦替尼布加 pembrolizumab 治疗期间可能发生的一种不良事件.
- 这种风险可能会在患有邻多发膜的肺转移的患者中升高.
- 这一案例强调了接受LP治疗的患者肺胸部监测的重要性.
相关概念视频
Pneumothorax-II
928
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
928
Pneumothorax-I
1.2K
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
1.2K
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
541
Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
541
Pulmonary Embolism III: Nursing Management
369
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
369
Endoscopic Studies II: Thoracocentesis
1.3K
Thoracentesis(Thoracocentesis), commonly known as pleural tap, is a medical procedure where a 22 gauge needle is inserted into the pleural space, the area between the lung and chest wall. This procedure is commonly performed to diagnose or treat various respiratory disorders.
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
1.3K
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
329
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
329

